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• Pharmaceutical effect on Membrance Permeability

  The antifungal azoles prevent the synthesis of ergosterol in the fungal membrane. These compounds block ergosterol synthesis by interfering with the demethylation of its precursor, lanosterol. Lanosterol demethylase is a cytochrome P450 enzyme and, although azole antifungals have much less influence on analogous mammalian systems, some of the side effects of these drugs are attributable to such action. Antifungal azole derivatives are predominantly fungistatic but some compounds at higher concentrations, notably miconazole and clotrimazole, kill fungi apparently by causing direct membrane damage. Other, less well characterized, effects of azoles on fungal respiration have also been described. ;

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