4214-85-1

The general procedure for the synthesis of 2-amino-6-methyl-5-nitro-3H-pyrimidin-4-one from 2-amino-4-hydroxy-6-methylpyrimidine was as follows: 2-amino-6-methylpyrimidin-4(3H)-one (50 g, 0.4 mol) was dissolved in 250 mL of concentrated sulfuric acid at 0°C, and 40 mL of concentrated nitric acid was slowly added through a dropping funnel. The reaction mixture was stirred at room temperature for 3 hours and then slowly poured into 3.6 L of diethyl ether and continued stirring for 15 minutes. The ether layer was decanted off and 1.0 L of ethyl acetate was added to the remaining solid and stirred for 10 hours. The solid product (54.8 g, 81% yield) was collected by filtration, which could be used in subsequent reactions without further purification.

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