420849-22-5

Dark Brown Solid

A cell permeable, potent PARP inhibitor with an IC50 of 450nM. Shown to be neuroprotective against oxygen-glucose deprivation injury in vitro in cultured murine cortical cells ( IC50 of 150nM) and i n vivi in rat transient focal ischemia model (3 mg/kg ip).

A cell permeable, potent PARP inhibitor with an IC50 of 450nM. Shown to be neuroprotective against oxygen-glucose deprivation injury in vitro in cultured murine cortical cells ( IC50 of 150nM) and in vivi in rat transient focal ischemia model (3 mg/kg ip).

TNKS2: 24 nM (IC₅₀); PARP2: 210 nM (IC₅₀); PARP15: 230 nM (IC₅₀); PARP10: >10 μM (IC₅₀); PARP14: >10 μM (IC₅₀)

Store at -20°C