42055-15-2

Colorless oil liquid

3-Methylamino-1-propanol is an alkanolamine that is used to redisperse compacted solids (such as antiperspirant materials) in order to analyze its components.

General procedure for the synthesis of 3-(methylamino)-1-propanol from the compound (CAS: 49807-74-1) as a raw material (34B): the product of Example 34a (8.60 g, 83.3 mmol) was dissolved in 10 mL of THF at 0 °C and slowly added to a 1 M solution of LAH THF (100 mL). The reaction mixture was heated to reflux for 3 hours. Upon completion of the reaction, water (3.79 mL) was carefully added, followed by 10% NaOH solution (11.4 mL) and water (3.79 mL). The resulting solid was removed by filtration and the solid was washed with additional THF (10 mL). The filtrates were combined and concentrated under reduced pressure to remove the solvent to afford 3-(methylamino)-1-propanol (4.40 g, 59% yield) as a yellow oil, which could be used in subsequent steps without further purification.1H NMR (300 MHz, CDCl3): δ 3.74 (m, 2H), 2.78 (m, 2H), 2.38 (s, 3H), 1.66 (q, J = 5.0 Hz, 2H).

[1] Patent: EP1820799, 2007, A1
[2] Patent: WO2006/51851, 2006, A1. Location in patent: Page/Page column 77-78
[3] Synthesis, 1986, # 4, p. 338 - 340
[4] Patent: US2004/24057, 2004, A1. Location in patent: Page/Page column 44
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 12, p. 2757 - 2762