4141-08-6

White Solid

2-Amino-N-methylbenzamide is a plant safening agent selected from auxins, auxin precursors, metabolites or derivatives, and acetaminophen or a derivative. Safening examples are provided for fertilizer s, fungicides, insecticides, and herbicides.

ChEBI: N-Methylanthranilamide is an aminobenzoic acid.

2-AMINO-N-METHYLBENZAMIDE is a key synthetic intermediate used to construct the core skeleton of FAK inhibitors (PA-DPPYs). It first reacts with 2,4,5-trichloropyrimidine (or 2,4-dichloro-5-nitropyrimidine) to form the 2-(2-chloro-5-substituted-pyrimidin-4-ylamino) -N-methylbenzamide intermediate, which is subsequently coupled with an aromatic amine containing a phosphate group to ultimately yield a series of bispyrimidine derivatives exhibiting anti-pancreatic cancer activity[6].

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 1, p. 164 - 167
[2] Patent: WO2011/140338, 2011, A1. Location in patent: Page/Page column 41
[3] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 61
[4] Patent: WO2004/80980, 2004, A1. Location in patent: Page 110-111
[5] Patent: US2013/225585, 2013, A1. Location in patent: Paragraph 0215; 0216