25900-61-2

General procedure for the synthesis of 3-amino-N-methylbenzamide from N-methyl-3-nitrobenzamide: A mixture of N-methyl-3-nitrobenzamide (2.47 g, 13.71 mmol) with 10% Pd/C catalyst (0.5 g) in methanol (50 mL) was subjected to hydrogenation at room temperature and atmospheric pressure overnight. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was subsequently concentrated. The resulting crude product was used directly in the subsequent reaction steps without further purification. (Yield: 2.06 g, 100%)

[1] Patent: US2004/97493, 2004, A1. Location in patent: Page/Page column 24
[2] Patent: US2010/160323, 2010, A1. Location in patent: Page/Page column 54
[3] Journal of Chemical Research, 2006, # 4, p. 223 - 224
[4] Patent: US5589489, 1996, A
[5] Patent: EP2774918, 2014, A1. Location in patent: Paragraph 0126; 0133