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2'',3''-Dideoxy-3''-fluorouridine is a reactant used in the synthesis of 5''-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase.

2′,3′-Dideoxy-3′-fluorouridine can be used as a starting material in the synthesis of:

• 3′-fluoro 2′,3′-dideoxynucleoside analogs for in vitro antiviral activity studies.
• 3′-fluoro deoxyuridine monophosphate analogs as potential anti parasites.

2′,3′-Dideoxy-3′-fluorouridine (3′-fluoro-2′,3′-dideoxyuridine, FddUrd) is a fluorinated pyrimidine nucleoside analog of uridine. It has been studied extensively for its potential use as an antiviral agent against HIV.