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To 2,4-dichloroquinoline (suspension in 100 mL of methanol) was added sodium methanolate (50 g). The reaction mixture was heated to reflux for 48 hours. After completion of the reaction, it was cooled to room temperature and the solid was separated by filtration. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was dissolved in water and extracted with dichloromethane (CH2Cl2). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give 2,4-dimethoxyquinoline as a white solid (13 g, 74% overall yield in two steps).