3970-68-1

169750-57-6

3970-68-1

General procedure for the synthesis of 4-methyl-4-hydroxypiperidine from benzyl 4-methylpiperidine-1-carboxylate: the Cbz-protected piperidine derivative mt 3-1 (1.5 g, 6.02 mmol) and Pd/C catalyst (0.3 g) were suspended in methanol (30 mL). The mixture was degassed under reduced pressure and displaced three times with hydrogen. Subsequently, the reaction mixture was stirred overnight at room temperature under hydrogen atmosphere (50 psi). Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to afford the target compound mt 3-2 (500 mg, 72% yield), which was used in subsequent steps without further purification. Mass spectrometric analysis (MS-ES) showed m/z: 116.3 ([M + H]+).