39544-74-6

Benzotript (39544-74-6) antagonizes the interaction of cholecystokinin and related peptides with the cholecystokinin receptor.1 ?It has been reported to potentiate morphine analgesia via interaction with opioid receptors.2

Benzotript is an antiulcer drug that is a cholecystokinin receptor (CCK-2R) antagonist .

1) Hahne (1981), Proglumide and benzotript: Members of a different class of cholecystokinin receptor antagonists; Proc. Natl. Acad. Sci. USA. 78 6304 2) Gaudreau et al. (1990), Cholecystokinin antagonists proglumide, lorglumide and benzotript, but not L-364,718, interact with brain opioid binding sites; Neuropeptides 16 51