3913-19-7

General procedure for the synthesis of 6-bromo-2-chloro-4-methylquinoline from 6-bromo-4-methyl-2(1H)-quinolinone: 25 mL of phosphorochloridic acid was added to 2.7 g (11.34 mmol) of 6-bromo-4-methyl-1H-quinolin-2-one (Example 1b), and the reaction mixture was refluxed for 2 hours. Upon completion of the reaction, it was cooled to room temperature and the mixture was slowly poured into 250 mL of 10% ammonia solution to precipitate. The precipitate was collected by filtration, washed with water and dried in a circulating air dryer at 30 °C. A product of 2.7 g was obtained in 93% yield. Product characterization: C10H7BrClN (M = 256.526); calculated molecular ion peak (M + H)+: 256/258/260 (BrCl); measured molecular ion peak (M + H)+: 256/258/260 (BrCl); Rf value: 0.95 (silica gel, dichloromethane/methanol 9:1).

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