Synthesis
To a solution of methyl-3,4-diflluoro-2-((2-flluoro-4-iodophenyl)amino)benzoate (23, 6.0 g, 23.8 mmol) in methanol (80 mL) and water (80 mL) was added LiOH (7.8 g, 195 mmol). The reaction mixture was stirred at 78 C in an oil bath for 1 h. After cooling, the reaction mixture was acidified to pH = 2 with a 2 N HCl solution. The solid was filtered and washed with water to provide 2-(2-Fluoro-4-iodoanilino)-3,4-difluoro benzoic Acid (5.11 g, 96%) as a white solid.
References
[1] Neuropharmacology, 2019, vol. 144, p. 122 - 132
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 33, p. 8551 - 8556
[3] Angew. Chem., 2013, vol. 125, # 33, p. 8713 - 8718,6
[4] Patent: WO2006/134469, 2006, A1. Location in patent: Page/Page column 13-14
[5] Patent: WO2004/56789, 2004, A1. Location in patent: Page 16; 23-24; 28; 31-32; 37-38
