Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine (Item No.
20248).
1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA.
3,1 Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 μM in CEM cells, which are used as a model for human T lymphoblasts.
1 It also halts the cell cycle at the sub-G
1 phase and induces apoptosis in CEM cells.
3 Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM)
ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.
4 
