37942-01-1

White to off-white crystal

The 5-Bromo-2-methoxyphenol is the important intermediate of producing depressor aliskiren.

The 5-bromo-2-methoxyphenol is synthesized by virtue of three steps of reactions as follows: by taking o-methoxyphenol as the raw materials, performing acetylation protection on the phenolic hydroxyl by use of acetic anhydride, and then performing bromination by use of bromine under the catalysis of iron powder, and finally performing deacetylation.