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LL-Z 1220 is a natural antibiotic containing a cyclohexene diepoxide ring system.

LL-Z1220 is a novel antibiotic with the structure of 2-(3,8-dioxopentacyclo[5.1.0.0^~^~]oct-5-en-5-yl)-4H-pyran-4-one. This appears to be the first reported natural product containing a benzene dioxide group. This antibiotic readily undergoes valence isomerization to form 1,4-dioxopentacyclo. The chemical and spectroscopic properties of the antibiotic suggest that the benzene dioxide has a cis configuration.

[1] Structure and Valence Isomerization of LL-Z1220. An Antibiotic Containing a Benzene Dioxide Moiety