Cyclamidomycin (Desdanine) is an acrylamide antibiotic with antibacterial activity. Cyclamidomycin inhibits nucleoside diphosphate kinase and pyruvate kinase (in E. coli) and oxidative phosphorylation in rat liver mitochondria. Cyclamidomycin is active against S. aureus, M. flavus, S. lutea, B. subtilis, E. coli, S. flexneri, S. typhosa, P. vulgaris, and K. pneumoniae (MICs=3.12-25 mg/ml)[1][2].
References
[1] Kazuhiko Otoguro, et al. Promising lead compounds for novel antiprotozoals. J Antibiot (Tokyo). 2010 Jul;63(7):381-4. DOI:10.1038/ja.2010.50 [2] S Takahashi, et al. A new antibiotic, cyclamidomycin. J Antibiot (Tokyo). 1971 Dec;24(12):902-3. DOI:10.7164/antibiotics.24.902
