354155-51-4

Endochin is an experimental antimalarial. Since the 1940s endochin and analogues thereof were known to be causal prophylactic and potent erythrocytic stage agents in avian models.

Endochin is an antimalarial agent. Endochin inhibits T.gondii with an IC50 of 0.003 nM. Endochin is also active against experimental toxoplasmosis[1][2].

Plasmodium

[1] Doggett JS, et al. Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15936-41. DOI:10.1073/pnas.1208069109
[2] Cross RM, et al. Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity. J Med Chem. 2010 Oct 14;53(19):7076-94. DOI:10.1021/jm1007903