3482-37-9

Yellow-green Solid

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

A minor alkaloid of the colchicine class, this base was first isolated from the seeds and corms of Colchicum autumnale, Gloriosa virescens and Littoria modesta and subsequently by Russian workers from Merendera robusta Bge. Several specific rotations have been measured, e.g. [α]_D - 184°, - 152° and - 180° (all in CHC13). The base is separated from the numerous accompanying alkaloids by chromatography and countercurrent distribution.

Potesilova, Hrbek, Santavy, Collect. Czech. Chem. Commun., 32, 141 (1967)
Trudykulov, Yusupov, Sadykov, Khim. Prir. Soedin., 8,247 (1972)
Yusupov, Tr. Tashkent Fan., Uzbek SSR, 20, 24 (1972)