34633-34-6

Bifluranol (BX341) is an anti-androgen.

ChEBI: (2S,3R)-bifluranol is a 4,4'-pentane-2,3-diylbis(2-fluorophenol) that has (2S,3R)-stereoconfiguration. It is an enantiomer of a (2R,3S)-bifluranol.

Bifluranol (BX341) has anti-androgenic activity.

The absorption, distribution and excretion of Bifluranol have been studied in mouse, rat, ferret and dog. It is readily absorbed following oral administration, but blood concentrations of Bifluranol are low due to hepatic uptake and biliary excretion. After intravenous administration of [ ³ H]it to rats (200 μg/kg) and ferrets (60 μg/kg) the blood concentrations of ³ H decreases rapidly for the first 2 to 3 h, with the decrease being more rapid in females ( 18 min for rat, 30 min for ferret) than males (1.0 h for rat, 1.4 h for ferret). This is followed by a much slower decline (40 h for rat). , 20 h for ferret) to concentrations at 96 h of less than 15 ng Bifluranol equivalents mL ^-1 (rat) or 1 ng Bifluranol equivalents mL ^-1 (ferret).

Store at -20°C

[1] Pope DJ, et al. Bifluranol, a novel fluorinated bibenzyl anti-androgen, its chemistry and disposition in different animal species. J Pharm Pharmacol. 1981 May;33(5):297-301. DOI:10.1111/j.2042-7158.1981.tb13784.x