344-65-0

393-36-2

344-65-0

The general procedure for synthesizing 2-bromo-5-chlorobenzotrifluoride from 5-amino-2-bromobenzotrifluoride was as follows: a diazonium salt solution was prepared according to the method described in Example 3. The cooled diazonium salt solution was slowly added to a pre-stirred and cooled mixture of CuCl (8.9 g, 0.091 mol) dissolved in concentrated hydrochloric acid (46 g, 0.44 mol). The reaction system was kept at a low temperature and when the addition was completed, it was gradually warmed up to room temperature with continuous stirring for 2 to 3 hours. Subsequently, the reaction mixture was heated to 60-70 °C to ensure complete reaction. Upon completion of the reaction, the target product 2-bromo-5-chlorobenzotrifluoride was obtained by isolation by appropriate methods. Yield: 65%.