340702-10-5

606080-43-7

340702-10-5

The general procedure for the synthesis of 6-fluoroisoindolin-1-one from methyl 2-cyano-5-fluorobenzoate was as follows: methyl 2-cyano-5-fluorobenzoate (10 g, 56 mmol) was dissolved in methanol (200 mL) at room temperature, followed by the addition of 10% palladium carbon catalyst (1.0 g). The reaction mixture was placed in a hydrogen (50 psi) atmosphere and the reaction was stirred overnight. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure to afford the target product 6-fluoroisoindolin-1-one as a colorless solid (8.0 g, 90% yield). Mass spectrometry (electrospray ionization): m/z calculated value C8H7FNO [M+H]+ 152, measured value 152.