329716-61-2

J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors[1].

hY₁ receptor: 1.4 nM (Ki); rNPY Y₁ receptor: 1.8 nM (Ki); mY1: 1.9 nM (Ki); hY₄ receptor: 620 nM (Ki); hY₅ receptor: 6000 nM (Ki); human Y₂ receptor: >10000 nM (Ki); mY6: >10000 nM (Ki)

[1] Kanatani A, et al. A typical Y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814. Mol Pharmacol. 2001 Mar;59(3):501-5. DOI:10.1124/mol.59.3.501