3289-47-2

7461-50-9

3289-47-2

The general procedure for the synthesis of 4-amino-2-methoxypyrimidine from 2-chloro-4-aminopyrimidine is as follows: Pre-step A: Synthesis of 2-methoxy-4-pyrimidinamine 2-Chloro-4-pyrimidinamine (150 mg, 1.158 mmol) and sodium methanol (188 mg, 3.47 mmol) were dissolved in methanol (2.9 mL) and the mixture was heated to 100°C in a Biotage microwave reactor for 40 min. Upon completion of the reaction, the crude product was purified by reversed-phase high performance liquid chromatography (RP-HPLC) to afford 2-methoxy-4-pyrimidinamine (73 mg, 0.583 mmol, 50% yield). Mass spectrum (electrospray positive ion mode) m/z 126.0 ([M+H]+).