32694-37-4

5α-dihydro-11-keto Testosterone is an analytical reference standard that is structurally classified as a steroid hormone. It is a metabolite of 11β-hydroxyandrostenedione and 11β-hydroxytestosterone that has been shown to act as a full androgen receptor agonist with equal potency as that of dihydrotestosterone . The androgenic activity of 5α-dihydro-11-keto testosterone has been implicated in contributing to the androgen pool that drives castration-resistant prostate cancer cells. This product is intended for forensic and research applications.

11-Ketodihydrotestosterone is a naturally occurring steroid and androgen prohormone that is produced primarily, if not exclusively, in the adrenal glands.

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[1]. bloem lm, storbeck kh, schloms l, et al. 11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function. molecules. 2013 oct 25;18(11):13228-44.
[2]. swart ac, storbeck kh. 11β-hydroxyandrostenedione: downstream metabolism by 11βhsd, 17βhsd and srd5a produces novel substrates in familiar pathways. mol cell endocrinol. 2015 jun 15;408:114-23.
[3]. storbeck kh, bloem lm, africander d, et al. 11β-hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel c19 steroids with androgenic activity: a putative role in castration resistant prostate cancer mol cell endocrinol. 2013 sep 5;377(1-2):135-46.