32618-85-2

General method: 2-cyano-4-nitroaniline (1 mmol) was added to an autoclave with KCC-1/IL NPs (0.0007 g). After sealing the autoclave, it was purged twice with carbon dioxide gas and subsequently filled with carbon dioxide to a pressure of 0.8 MPa. The reaction system was heated to 70 °C and maintained for 60 min for the reaction. After completion of the reaction, the autoclave was cooled to room temperature and the reaction mixture was transferred to a 50 mL round bottom flask. The completion of the reaction was confirmed by monitoring the progress of the reaction by thin layer chromatography (TLC). Ethanol was added to the reaction mixture and subsequently the KCC-1/IL NPs were separated by vacuum distillation.The solvent was evaporated under reduced pressure and the resulting crude product was purified by recrystallization through a solvent mixture of n-hexane/ethyl acetate to give 2,4-dihydroxy-6-nitroquinazoline.

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