ChemicalBook CAS DataBase List 3232-36-8

3232-36-8

Name	SALICYLIDENE SALICYLHYDRAZIDE
CAS	3232-36-8
EINECS(EC#)	221-773-2
Molecular Formula	C14H12N2O3
MDL Number	MFCD00043494
Molecular Weight	256.26
MOL File	3232-36-8.mol

Synonyms

2-HYDROXYBENZYLIDENE 2-HYDROXYBENZHYDRAZIDE 2-HYDROXYBENZYLIDENE SALICYLHYDRAZIDE NSC 87864 SALICYLIDENE SALICYLHYDRAZIDE SALICYLIDENE SALICYLHYDRAZONE SCS TIMTEC-BB SBB007781 2-hydroxy-benzoicaci[(2-hydroxyphenyl)methylene]hydrazide (2-hydroxybenzylidene)salicylohydrazide Salicylidenesalicylhydrazide,97% 2-Hydroxybenzylidene 2-hydroxybenzhydrazide, NSC 87864, SCS (2-Hydroxyphenyl)[2-(2-hydroxybenzylidene)hydrazono]methanol 1-(2-Hydroxybenzoyl)-2-(2-hydroxybenzylidene)hydrazine 1-Salicylidene-2-salicyloylhydrazine 1-Salicyloyl-2-salicylidenehydrazine N'-(2-Hydroxybenzylidene)-2-hydroxybenzhydrazide N'-Salicylidenesalicylic hydrazide

Chemical Properties

Melting point	280-284°C
storage temp.	Store at RT
solubility	DMSO: ~20 mg/mL
form	solid
color	off-white
BRN	2944701
CAS DataBase Reference	3232-36-8(CAS DataBase Reference)
EPA Substance Registry System	Benzoic acid, 2-hydroxy-, [(2-hydroxyphenyl)methylene]hydrazide (3232-36-8)

Safety Data

Hazard Codes	Xn
Risk Statements	R22:Harmful if swallowed. less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . less more
WGK Germany	3
TSCA	Yes
HS Code	29280000

Hazard Information

Uses

SCS is a selective inhibitor of β1-containing GABAA receptors.

Definition

ChEBI: 2-hydroxy-N'-[(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]benzohydrazide is a member of salicylamides.

Biological Activity

Potent and selective partial inhibitor of β 1-containing GABA A receptors (IC 50 values are 4.5, 5.3 and 7.9 nM at α 2 β 1 γ 1 θ , α 2 β 1 γ 1 and α 2 β 1 γ 2s GABA A receptors respectively). May bind allosterically to a novel site on GABA A receptor.

in vivo

SCS (Salicylidene salicylhydrazide; 500-1000 mg/kg, i.p. or 800-1000 mg/kg, oral) produces abdominal constrictions in mice^[2].
SCS (10-75 mg/kg; i.p.; once) shows antinociceptive activity against tonic, phasic and Capsaicin (HY-10448) nociception in mice^[2].
SCS (10-75 mg/kg; i.p.; once) shows anti-inflammatory activity in mice^[2]. SCS (50 and 75 mg/kg; i.p.; once) shows antinociceptive activity against neuropathic nociception^[2].

Animal Model:	BALB/c mice; tonic, phasic and Capsaicin (HY-10448) nociception model^[2]
Dosage:	10, 25, 50, and 75 mg/kg
Administration:	IP, single dose
Result:	Produced a significant protection on tonic, phasic and capsaicin nociception in a dose-dependent manner.

Animal Model:	BALB/c mice, Oxaliplatin (HY-17371)-induced neuropathic nociception model^[2]
Dosage:	50 and 75 mg/kg
Administration:	IP, single dose
Result:	Significantly attenuated the paw withdrawal threshold changes associated with Oxaliplatin. Significantly increased the percent antinociception during 30-120 min.

storage

Store at RT

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

Meryer (Shanghai) Chemical Technology Co., Ltd.

Telephone4006356688 18621169109

Websitehttp://www.x-labseek.com/

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0_EN.htm

Alfa Aesar

Telephone400-6106006

Websitehttp://chemicals.thermofisher.cn

Energy Chemical

Telephone 400-0056266

Websitehttp://www.energy-chemical.com

Bide Pharmatech Ltd.

Telephone400-164-7117 18317119277

Websitehttp://www.bidepharm.com

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 15026964105

Websitehttps://www.shyuanye.com

Dalian lichuang Chemical Co., Ltd

Telephone0411-0411-00000000 13644282108

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList20133/0_EN.htm

Aikon International Limited

Telephone025-58859352 15955137747

Websitehttp://www.aikonchem.com

Career Henan Chemica Co

Telephone+86-0371-86658258 +86-13203830695

Websitehttps://www.coreychem.com/

Shanghai Minhan Pharmaceutical Technology Co., Ltd.

Telephone 17612188245

Websitehttp://www.suppliers.integle.com

Shaanxi Dideu Medichem Co. Ltd

Telephone+86-029-81138252 +86-173 9270 1263

Websitehttps://www.chemicalbook.com/manufacturer/shaanxi-dideu-medichem-222/

MedBioPharmaceutical Technology Inc

Telephone021-69568360 18916172912

Websitehttp://www.med-bio.cn/

Hubei yongkuo Technology Co., Ltd

Telephone027-59223108 15972152991

Websitehttps://www.hbyongkuo.com/contact.html

Hubei Xinkang Pharmaceutical Chemical Co., Ltd

Telephone027-027-59308705 18871579363

Websitehttp://www.xin-api.com/

Tianmen Hengchang Chemical Co., Ltd

Telephone027-59322316 15172518801

Websitehttp://www.tianmenchem.com/

Shanghai kadel chemical technology co., LTD

Telephone021-4007787-550 400-7787-550

Websitehttp://www.jadell.com.cn/

Hangzhou Taorui Biotechnology Co., Ltd

TelephoneQQ1259737804 15268198094

Websitehttp://www.torreybio.com/

TCI (Shanghai) Chemical Trading Co., Ltd.

Telephone021-61109150

Websitehttps://www.tcisct.com

1of4

Related Products

Send Inquriy