320386-54-7

3-Mercaptopicolinic acid is an inhibitor of gluconeogenesis. In perfused rat livers, gluconeogenesis was inhibited when lactate, pyruvate, or alanine served as substrate, but not with fructose, suggesting phosphoenolpyruvate carboxykinase as the site of inhibition.

Light Yellow Solid

A potent inhibitor of gluconeogenesis.

Store at -20°C

[1] N W DITULLIO. 3-mercaptopicolinic acid, an inhibitor of gluconeogenesis.[J]. Biochemical Journal, 1974, 138 3: 387-394. DOI: 10.1042/bj1380387
[2] B.H. ROBINSON  J. O. 3-Mercaptopicolinic acid, a preferential inhibitor of the cytosolic phosphoenolpyruvate carboxykinase[J]. FEBS Letters, 1975, 58 1: Pages 12-15. DOI: 10.1016/0014-5793(75)80214-6
[3] JORGE HIDALGO. Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors.[J]. PLoS ONE, 2016: e0159002. DOI: 10.1371/journal.pone.0159002