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(Polyinosinic-polycytidylic acid potassium salt) TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid (Poly(I) • Poly(C)) is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

Polyinosinic-polycytidylic Acid Potassium Salt triggers apoptosis in some cancer cells.