316146-57-3

ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2. ICA-105574 shifts the voltage dependence of Ptype inactivation to a very positive direction and removes the hERG channel from inactivation at physiological membrane potentials[1].

[1] Mahoko Asayama . “Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts.” Journal of pharmacological sciences 121 1 (2013): Pages 1-8.