30685-57-5

Homouridine, is an uridine analogue. Homouridine serves as an intermediate to prepare MMP-2 inhibitor (compund I, IC50=150 μM). Homouridine derivate (compund I) also inhibits TNF-α binding to TNF-αR1[1].

[1] Hsu Li-Wei, et al. Uridine derivatives as matrix metalloproteinase (MMP) and tumor necrosis factor (TNF) inhibitors for the treatment of cancer. European Patent Organization, EP1338282 A1. 2003-08-27.