3038183-53-5

JAK2/FLT3-IN-3 (11r) is a dual FLT3 and JAK2 inhibitor, with IC50 values of 2.01 nM, 0.51 nM and 104.40 nM for JAK2, FLT3 and JAK3, respectively. JAK2/FLT3-IN-3 (11r) induces apoptosis and possesses antitumor activity[1].

JAK2: 2.01 nM (IC₅₀); FLT3: 0.51 nM (IC₅₀); JAK3: 104.40 nM (IC₅₀)

[1] Sicong Xu, et al. 2-Aminopyrimidine derivatives as selective dual inhibitors of JAK2 and FLT3 for the treatment of acute myeloid leukemia. Bioorg Chem. 2023 May:134:106442. DOI:10.1016/j.bioorg.2023.106442