DDA1
PCIA1
C19orf58
DET1- and DDB1-associated protein 1
ANTI-PCIA1 (CENTER) antibody produced in rabbit
5-Thiazolecarboxamide, 2-[[6-[4-[[1-[8-[4-[4-[(2-aminoethyl)amino]-2-[1-(4-chlorophenyl)cyclohexyl]-7-quinazolinyl]-1-piperazinyl]-8-oxooctyl]-4-piperidinyl]oxy]-1-piperidinyl]-2-methyl-4-pyrimidinyl]amino]-N-(2-chloro-6-methylphenyl)-
DDa-1 is a potent BTK degrader (DC50: 90 nM). Blue: DCAF1 binder (HY-149934), Black: linker, Pink: BTK ligand (HY-107447)[1].
References
[1] Schr?der M, et al. DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance. Nat Commun. 2024 Jan 4;15(1):275. DOI:10.1038/s41467-023-44237-4
