300-62-9

Name	D/L-AMPHETAMINE HYDROCHLORIDE
CAS	300-62-9
EINECS(EC#)	206-096-2
Molecular Formula	C9H14ClN
MDL Number	MFCD01708024
Molecular Weight	171.67
MOL File	300-62-9.mol

Chemical Properties

Appearance	Amphetamine is a mobile liquid with an amine odor.
Melting point	146 °C
Boiling point	bp760 200-203°; bp13 82-85°
density	d425 0.913
vapor density	4.65
refractive index	1.5180 (estimate)
Fp	9℃
storage temp.	?20°C
solubility	Chloroform (Slightly)
form	Liquid or oil
pka	9.94±0.10(Predicted)
EPA Substance Registry System	Amphetamine (300-62-9)

Safety Data

Hazard Codes	F,T
Risk Statements	11-23/24/25-39/23/24/25 less more
Safety Statements	16-36/37-45-7 less more
RIDADR	1851
WGK Germany	1
HazardClass	6.1(a)
PackingGroup	II
Safety Profile	A deadly human poison by an unspecified route. An experimental poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Experimental reproductive effects. Mutation data reported. A central nervous system stimulant. Overdoses cause hyperactivity, restlessness, insomnia, rapid pulse, rise in blood pressure, dilated pupils, dryness of the throat. Combustible when exposed to heat, flame, or oxidizers. When heated to decomposition it emits toxic fumes of NO,. To fight fire, use CO2, dry chemical, alcohol foam, water mist, fog. See other benzedrine entries. less more
Hazardous Substances Data	300-62-9(Hazardous Substances Data)
Toxicity	LD50 in rats (mg/kg): 180 s.c. (Warren, Werner) less more

Raw materials And Preparation Products

Hazard Information

Chemical Properties

Colorless, volatile liquid; characteristic strong odor; slight burning taste. Soluble in alcohol and ether; slightly soluble in water.

Uses

Stimulant (central).

Brand name

Benzadrine (SmithKline Beecham).

General Description

Colored liquid with an amine odor. Used as a pharmaceutical, a central nervous system stimulant.

Reactivity Profile

Amines, such as D/L-AMPHETAMINE HYDROCHLORIDE, are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Hazard

Flammable, moderate fire risk. Basis of a group of hallucinogenic (habit-forming) drugs that affect the central nervous system. Sale and use restricted to physicians. Production limited by law.

Health Hazard

D/L-AMPHETAMINE HYDROCHLORIDE is classified as extremely hazardous. Probable lethal dose in humans is 5-50 mg/kg or 7 drops to 1 teaspoon for a 70 kg (150 lb.) person. Habit forming drug which affects the central nervous system. Excessive use may lead to tolerance and physical dependence. Death is possible.

Fire Hazard

Dangerous when exposed to heat or flames. Upon decomposition, nitrogen oxides are emitted. Can react with oxidizing materials.

Potential Exposure

Amphetamine is used as a pharmaceutical. It is a CNS stimulant.

First aid

Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Description

Amphetamine is a mobile liquid with an amineodor. Molecular weight= 135.23; Boiling point=200°203℃; Flash point #100℃. Hazard Identification(based on NFPA-704 M Rating System): Health 4,Flammability 1, Reactivity 0. Slightly soluble in water.

Waste Disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

Definition

ChEBI: 1-phenylpropan-2-amine is a primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.

World Health Organization (WHO)

Amfetamine and its derivatives are potent central stimulants. Use of amfetamines has widely been discouraged due to abuse of their euphoric effect and their limited field of usefulness. Amfetamines have a place in the treatment of narcolepsy and in hyperkinetic syndrome in children. However, they are no longer recommended for use in obesity or depressive illness. Amfetamine is controlled under Schedule II of the 1971 Convention on Psychotropic Substances. (Reference: (UNCPS2) United Nations Convention on Psychotropic Substances (II), , , 1971)

Environmental Fate

Amphetamines are indirect acting sympathomimetics, producing their effects by inhibiting the transporters of dopamine, norepinephrine, and serotonin at the presynaptic nerve terminal. This increases the release of norepinephrine, dopamine, and serotonin and increased norepinephrine levels at central synapses, which further stimulates alpha and beta receptors. Some amphetamines also inhibit monoamine oxidase, preventing the breakdownof catecholamines. Thesemechanisms combine to produce the sympathomimetic and central nervous system (CNS) effects seen with amphetamine abuse.

storage

Color Code—Blue: Health Hazard/Poison: Store ina secure poison location. Prior to working with this chemicalyou should be trained on its proper handling and storage.Store in a refrigerator or a cool, dry place.

Toxicity evaluation

Amphetamine is a clear to colorless liquid in freebase or white crystalline substance as a salt. As a liquid it slowly volatilizes and has a characteristic amine odor. Amphetamine base is slightly soluble in water, soluble in alcohol and ether. The melting point of amphetamine is 300 C with some decomposition occurring.

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