29936-81-0

PTP inhibitor III (29936-81-0) inhibits a broad range of protein tyrosine phosphatases (PTPs). Binds covalently to the active site of the enzyme.1-2? Blocks SHP1-mediated dephosphorylation of TRPV1 in dorsal root ganglion neurons aggravating CFA-induced inflammatory pain.3

PTP Inhibitor III is an α-haloacetophenone derivative that acts as a photoreversible covalent inhibitor of protein tyrosine phosphatases (PTPs). It binds the catalytic domain of SHP-1 (Ki = 184 μM) and covalently reacts with free thiols, a reaction that is reversible with irradiation (350 nm). PTP Inhibitor III is cell permeable and inhibits a broad range of PTPs.[Cayman Chemical]

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Kanda et al. (2006), Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase; J. Biol. Chem., 281 28518 Popov et al. (2009), Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction; Biochem. Biophys. Res. Commun., 389 1 Xiao et al. (2015), Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats; Pain, 156 597