Diapocynin (300 mg/kg; p.o.; every 12 hours for 72 hours) significantly rescues DFP-induced motor impairment, attenuates epileptiform spiking during the first 72h post-DFP. Diapocynin significantly reduces DFP-induced reactive astrogliosis, neurodegeneration, GP91phox, glutathiolated protein, serum nitrite, or pro-inflammatory cytokines and chemokines such as interleukins (IL) IL-1α, IL-6, IL-2, IL-17A, Leptin, IP-10 in the hippocampus[1].
| Animal Model: | Adult male Sprague-Dawley rats (200 g; 7-8 weeks old) injected with Diisopropylfluorophosphate (DFP)[1] |
| Dosage: | 300 mg/kg |
| Administration: | p.o.; every 12 hours for 72 hours |
| Result: | Significantly rescued DFP-induced motor impairment.
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