ChemicalBook CAS DataBase List 292618-32-7

292618-32-7

Name	ST1481
CAS	292618-32-7
Molecular Formula	C25H25N3O5
MDL Number	MFCD06795143
Molecular Weight	447.49
MOL File	292618-32-7.mol

Chemical Properties

Boiling point	780.6±70.0 °C(Predicted)
density	1.37±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
form	Solid
pka	11.20±0.20(Predicted)
color	Light yellow to yellow

Safety Data

Symbol(GHS)	GHS07,GHS08,GHS06
Signal word	Danger
Hazard statements	H300-H335-H319-H351-H315
Precautionary statements	P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

Hazard Information

Uses

Gimatecan (ST1481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity[1].

Biological Activity

Gimatecan (ST1481) is a potent topoisomerase I inhibitor. It is an orally active camptothecin analog with antineoplastic activity.

in vivo

Gimatecan (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth.

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target

Animal Model:	Athymic Swiss nude mice bearing HT1376 model
Dosage:	2 mg/kg
Administration:	Treatment per os, every fourth day for four times
Result:	Caused a marked tumor growth inhibition during treatment.

Topoisomerase I

IC 50

Topoisomerase I

storage

Store at -20°C

References

[1] Paola Ulivi, et al. Cellular Basis of Antiproliferative and Antitumor Activity of the Novel Camptothecin Derivative, Gimatecan, in Bladder Carcinoma Models. Neoplasia. 2005 Feb;7(2):152-61. DOI:10.1593/neo.04397

Spectrum Detail

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