2924824-56-4

ARUK2001607 is a selective phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ)?inhibitor with a Kd of 7.1 nM. ARUK2001607 shows high selectivity over other >150 kinases[1].

[1] Timothy P C Rooney, et al. The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. J Med Chem. 2022 Dec 14. DOI:10.1021/acs.jmedchem.2c01693