ChemicalBook CAS DataBase List 2919575-27-0

2919575-27-0

Name	Ethanone, 1-[7-[[2-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyridinyl]amino]-2,3-dihydro-1H-indol-1-yl]-
CAS	2919575-27-0
Molecular Formula	C27H32N6O
Molecular Weight	456.58
MOL File	2919575-27-0.mol

Chemical Properties

Boiling point	677.0±55.0 °C(Predicted)
density	1.243±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
solubility	DMF: 1 mg/mL DMSO: 1 mg/mL Ethanol: Slightly SolublePBS (pH 7.2): Slightly soluble
form	Solid
pka	8.22±0.10(Predicted)
color	White to off-white

Hazard Information

Uses

UCL-TRO-1938 is a potent small molecule allosteric activator of PI3Kα with an EC50 value of approximately 60 μM. UCL-TRO-1938 can induce cell proliferation and has cardioprotective effects from ischaemia reperfusion injury and enhances nerve regeneration following nerve crush[1][2][3][4][5].

in vivo

UCL-TRO-1938 (10 mg/kg or 5 μM, 100 μM, i.v., a single dose 15 min prior to reperfusion or a single dose for 21 days) provides cardioprotection and stimulates nerve regeneration in model of ischaemia reperfusion injury in mice and rat sciatic nerve crush model of peripheral nerve injury and regeneration^[1].

Animal Model:	Model of ischaemia reperfusion injury in mice and rat sciatic nerve crush model of peripheral nerve injury and regeneration
Dosage:	10 mg/kg or 5 μM, 100 μM
Administration:	i.v., a single dose 15 min prior to reperfusion or a single dose for 21 days
Result:	Provided substantial tissue protection from IRI, increasing tissue survival and reducing infarct size, and significantly increased neurite outgrowth in dissociated adult rat dorsal root ganglion (DRG) cultures.

References

[1] Gong GQ, et al. A small-molecule PI3Kα activator for cardioprotection and neuroregeneration. Nature. 2023 Jun;618(7963):159-168. DOI:10.1038/s41586-023-05972-2
[2] Shi H, et al. miR-30c-5p inhibits esophageal squamous cell carcinoma progression by repressing the PI3K/AKT signaling pathway. Thorac Cancer. 2024 Oct;15(30):2206-2216. DOI:10.1111/1759-7714.15427
[3] Najam O. Exploring the role of cardiac mast cells in acute myocardial infarction and ischaemia-reperfusion injury[D]. UCL (University College London), 2023.
[4] Kingwell K. PI3K activator taps route to regeneration. Nat Rev Drug Discov. 2023 Jul;22(7):537. DOI:10.1038/d41573-023-00097-7
[5] Ni C, et al. An inappropriate decline in ribosome levels drives a diverse set of neurodevelopmental disorders. bioRxiv [Preprint]. 2024 Jan 9:2024.01.09.574708. DOI:10.1101/2024.01.09.574708

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