288104-79-0

Name	Surinabant
CAS	288104-79-0
Molecular Formula	C23H23BrCl2N4O
MDL Number	MFCD09970803
Molecular Weight	522.26
MOL File	288104-79-0.mol

Synonyms

SR147778 SR-147778 SR 147778 Surinabant 5-(4-Bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide 1H-Pyrazole-3-carboxamide, 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-1-piperidinyl- 1-(2,4-Dichlorophenyl)-5-(4-bromophenyl)-4-ethyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

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Chemical Properties

density	1.50
pka	11.30±0.20(Predicted)

Hazard Information

Uses

Surinabant (SR 147778) is an orally active, selective cannabinoid receptor type 1 CB1R antagonist. Surinabant is used in studies of obesity and alcoholism[1][2].

Definition

ChEBI: 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-3-pyrazolecarboxamide is a member of pyrazoles and a ring assembly.

References

[1] Klumpers LE, et al. Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits Δ9-tetrahydrocannabinol-induced central nervous system and heart rate effects in humans. Br J Clin Pharmacol. 2013 Jul;76(1):65-77. DOI:10.1111/bcp.12071
[2] Fischler PV, et al. Off-label and investigational drugs in the treatment of alcohol use disorder: A critical review. Front Pharmacol. 2022 Oct 3;13:927703. DOI:10.3389/fphar.2022.927703

Supplier

Jinan Ruisi Pharmaceutical Technology Co., LTD

Telephone0531-0531-69900633 19963472814

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList31265/0_EN.htm

CONIER CHEM AND PHARMA LIMITED

Telephone

Websitehttp://www.conier.com/

Henan Yinuokai New Materials Co., Ltd

Telephone15565215982 15565215982

Websitehttps://www.chemicalbook.com/supplier/131630565/

GZanlihe

Telephone13928234501 18098185186

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