General procedure for the synthesis of 2,4,5-trifluorobenzenesulfonamides from 2,4,5-trifluorobenzenesulfonyl chloride: ammonium hydroxide (NH4OH, 910 mg, 26 mmol) was slowly added to a solution of 2,4,5-trifluorobenzene-1-sulfonyl chloride (3.0 g, 13 mmol) in tetrahydrofuran (THF, 30 mL). The reaction mixture was stirred at room temperature for 14 hours. Upon completion of the reaction, the solution was concentrated under reduced pressure to afford 2,4,5-trifluorobenzenesulfonamide (2.7 g, 13 mmol, 98% yield) as a yellow solid. The product was analyzed by electrospray ionization mass spectrometry (ESI-MS) and showed a molecular ion peak (EI+, m/z): 211.9 [M+H]+.
