Orientin is a flavone glycoside originally isolated from
P. orientale that has diverse biological activities, including antioxidant, antibacterial, and anti-inflammatory properties.
1,2,3,4 Orientin scavenges 2,2-diphenyl-1-picryl-hydrazyl (DPPH; Item No.
14805) radicals with an IC
50 value of 316.21 μg/ml.
2 It also decreases the cytopathic effects of parainfluenza type 3 virus with an IC
50 value of 11.7 μg/ml and a cytotoxic concentration (CC
50) value of 375 μg/ml in Hep-2 cells.
3 Orientin (5-40 μM) inhibits LPS-induced barrier disruption, decreases the expression of toll-like receptor 4 (TLR4), phosphorylated p38, and NF-κB, and decreases TNF-α production and IL-6 secretion in a dose-dependent manner in human umbilical vein endothelial cells (HUVECs).
4 It also prolongs survival in a mouse model of LPS-induced lethal endotoxemia when administered at a dose of 36 μg/animal 12 hours after LPS administration.
