2796282-58-9

HDAC6-IN-9 (compound 12c) is a potent and selective HDAC6 inhibitor with IC50 values of 11.8, 15.2, 4.2, 139.6, 21.3 nM for HDAC1,HDAC3, HDAC6, HDAC8, HDAC10, respectively. HDAC6-IN-9 shows anti-proliferative activities[1].

HDAC1: 11.8 nM (IC₅₀); HDAC3: 15.2 nM (IC₅₀); HDAC6: 4.2 nM (IC₅₀); HDAC8: 139.6 nM (IC₅₀); HDAC10: 21.3 nM (IC₅₀)

[1] Li X,et al. Design, Synthesis, and biological evaluation of HDAC6 inhibitors based on Cap modification strategy. Bioorg Chem. 2022 Aug;125:105874. DOI:10.1016/j.bioorg.2022.105874