2772746-58-2

Name	hydrochloride
CAS	2772746-58-2

Synonyms

2-[[4-[4-(2-methoxyphenyl)piperidin-1-yl]-2-(1-methylcyclopropyl)quinazolin-6-yl]-methylamino]ethanol

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Chemical Properties

form	Solid
color	Light yellow to yellow

Hazard Information

Uses

SBI-810 hydrochloride is a functionally selected β-arrestin-biased neurotensin receptor 1 (NTSR1) allosteric modulator. SBI-810 hydrochloride modulates NTSR1 G protein signaling in a G protein-specific manner in the presence of the endogenous ligand, neurotensin (NT). SBI-810 hydrochloride fully antagonizes NT-induced activation of Gq, partially antagonizes NT-induced activation of Gi1 and is permissive of NTSR1 activation of GoA and G12[1][2].

References

[1] Lawrence Barak, et al. Compositions for and methods of treating and/or preventing pain. WO2022241186A1. 2022 November 17.
[2] Center M N A, et al. Summer Undergraduate Research Expo[J]. 2014.

Supplier

Shanghai Chaolan Chemical Technology Center

TelephoneQQ：65489617 13301690235

Websitehttp://www.atkchemical.com/

Suzhou Chenrui Biotechnology Co. LTD

Telephone 17625585511

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList660257/0_EN.htm

Nantong Hi-Future Biotechnology Co., Ltd

Telephone+86-0513; 18051384581

Websitehttps://www.chemhifuture.com/

Henan Yinuokai New Materials Co., Ltd.

Telephone 15670530983

Website

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