2771297-34-6

CYP3A4-IN-1 (compound 5a) is a potent cytochrome P450 3A4 (CYP3A4) inhibitor with an IC50 value of 0.085 μM[1].

CYP3A4: 0.085 μM (IC₅₀)

[1] Samuels ER, et al. An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg Med Chem. 2020 Mar 15;28(6):115349. DOI:10.1016/j.bmc.2020.115349