2768759-64-2

Name	INDEX NAME NOT YET ASSIGNED
CAS	2768759-64-2
Molecular Formula	C16H19N2NaO5S
Molecular Weight	374.39
MOL File	2768759-64-2.mol

Synonyms

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Chemical Properties

storage temp.	Store at -20°C
solubility	DMSO: soluble
form	A crystalline solid

Hazard Information

Uses

NLRP3-IN-9 is a potent NLRP3 inhibitor. NLRP3-IN-9 inhibits IL-1β release. NLRP3-IN-9 reduces inflammation and mechanical hyperalgesia. NLRP3-IN-9 has the potential for the research of gout[1].

in vivo

NLRP3-IN-9 (3, 10 mg/kg; i.p.) reduces inflammation and mechanical hyperalgesia in a mouse model of acute gout^[1].

Animal Model:	3-4 month old male and female C57BL/6J WT and NLRP3-KO mice^[1]
Dosage:	3, 10 mg/kg
Administration:	I.p.
Result:	Reduced paw swelling by 40% in males and 33% in females at 3 mg/kg, and 66% in males and 52% in females at 10 mg/kg in WT mouse.

IC 50

NLRP3

References

[1] Narros-Fernández P, et al. Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout. J Med Chem. 2022 Apr 28;65(8):6250-6260. DOI:10.1021/acs.jmedchem.2c00149

Supplier

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Cayman Chemical Company

Telephone800-364-9897

Websitehttp://www.caymanchem.com

Shenzhen Campbell Biotechnology Co., Ltd.

Telephone18028747627

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1668922/0_EN.htm

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