2765081-21-6

RMC-6236 (3-25 mg/kg; p.o.; single dose) shows dose-dependent blood and tumor exposure in the Capan-2 xenograft tumor-bearing BALB/c nude mouse model, with tumor exposure approximately 3-7 times higher than that in blood and relatively slower elimination from tumors^[1].
RMC-6236 (10-25 mg/kg; p.o.; once daily; 4 weeks) shows dose-dependent antitumor activity in a series of human tumor xenograft models harboring prevalent KRAS mutations (such as Capan-2, NCI-H441, HPAC, NCI-H358, etc.)^[1].
RMC-6236 (25 mg/kg; p.o.; once daily) can arrest tumor growth when used alone in xenograft models of KRAS^G12C-mutant NCI-H2122 non-small cell lung cancer and KRAS^G12D-mutant GP2D colorectal cancer, and it can lead to significant tumor regression when combined with KO-2806^[2].