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Taspoglutide with -methylalanine in greatly retard degradation by DPP-IV and neutral endopeptidase24.11, respectively (see preceding discussion for exenatide).The phase III trials, which commenced in 2008, arebeing conducted with a zinc-based preparation, prolongingthe duration in a manner similar to zinc-containing insulinpreparations, so that once-weekly injections of 20 to 30 mgwill be possible.

Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist. Taspoglutide improves glucose tolerancepostprandial glucosebody weightglycaemic control and insulin sensitivity in the Zucker diabetic fatty rat.

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