2748469-82-9

5-hydroxy Indole-3-acetic acid-d6 (5-HIAA-d6) is intended for use as an internal standard for the quantification of 5-HIAA (Item No. 22889) by GC- or LC-MS. 5-HIAA is a metabolite of the monoamine neurotransmitter serotonin (5-HT; Item No. 14332).1 It is formed from serotonin via a 5-hydroxy indole-3-acetaldehyde intermediate by aldehyde dehydrogenase. 5-HIAA has been used as a biomarker for the detection of neuroendocrine tumors. Brain levels of 5-HIAA are decreased in patients with severe Alzheimer’s disease.2WARNING This product is not for human or veterinary use.

[1] JEAN-BENOÎT CORCUFF. Urinary sampling for 5HIAA and metanephrines determination: revisiting the recommendations.[J]. Endocrine Connections, 2017, 6 6: R87-R98. DOI: 10.1530/ec-17-0071
[2] YANNICK VERMEIREN . Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer’s disease[J]. Neurobiology of Aging, 2014, 35 12: Pages 2691-2700. DOI: 10.1016/j.neurobiolaging.2014.05.031