2469263-61-2

Serotonin-d₄ is intended for use as an internal standard for the quantification of serotonin by GC- or LC-MS. Serotonin is a monoamine neurotransmitter that is biochemically derived from tryptophan and produced in serotonergic neurons in the central nervous system and in enterochromaffin cells in the gastrointestinal tract.^1,2,3,4 Serotonin is important in the regulation of mood, sleep, vomiting, sexuality, and appetite. Low levels of serotonin are associated with several disorders, including depression, migraines, bipolar disorder, and anxiety. Its actions are terminated primarily via uptake of serotonin from the synapse. Serotonin reuptake can be inhibited with MDMA, cocaine, tricyclic antidepressants, and selective serotonin reuptake inhibitors.

1. Martinez, A., Knappskog, P.M., and Haavik, J. A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosyntheis Curr. Med. Chem. 8(9),1077-1091(2001).
2. Liu, Q., Yang, Q., Sun, W., et al. Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract J. Pharmacol. Exp. Ther. 325(1),47-55(2008).
3. Schmid, C.L., and Bohn, L.M. Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a β-arrestin2/Src/Akt signaling complex in vivo J. Neurosci. 30(40),13513-13524(2010).
4. Berger, M., Gray, J.A., and Roth, B.L. The expanded biology of serotonin Annu. Rev. Med. 60,355-366(2009).