27465-51-6

4'-Ethylpropiophenone is a synthetic chemical that belongs to the class of piperidine hydrochloride. It emits light when it reacts with inorganic acid and has a constant for its wavelength. It is synthesized by the reaction of crambidae with molybdenum, which results in the formation of hydroxyl group and chloride. The compound can be dehydrated by reacting with hydroxyl group and chloride, which leads to its formation. 4'-Ethylpropiophenone has been shown to have an effect on lepidoptera larvae, acting as an insecticide, but has not been studied for effects on humans or other mammals.

Clear colorless liquid

An impurity of Eperisone (E565800) as muscle relaxant and analgesic.

GENERAL STEPS: Amide (0.5 mmol), PEPPSI catalyst (0.025 mmol, 5 mol%), and K2CO3 (2 eq.) were added to a 20 mL Schlenk tube under nitrogen protection, followed by degassing of the system and replacement with nitrogen three times. Methyl tert-butyl ether (MTBE, 6.0 mL) was added via syringe as solvent, followed by 0.75 mL (1.5 eq.) of borane solution (1 M in THF, commercially available or prepared in situ by borohydride reaction of olefins). The reaction mixture was stirred at room temperature in a nitrogen atmosphere for 24 hours. Upon completion of the reaction, the reaction was quenched with ice water (5 mL) and extracted with MTBE (2 x 5 mL). The organic phases were combined and dried with anhydrous Na2SO4. After filtration, the solvent was removed by rotary evaporator to obtain the crude product. The crude product was purified by rapid column chromatography on silica gel, and the eluent was a mixed petroleum ether/ethyl acetate solvent.

[1] Molecules, 2018, vol. 23, # 10,